Androvia LifeSciences has developed a brand-new test which is capable of measuring male infertility. Up until now, current methods have been unable to explain over half of male infertility cases. So, could this new test prove evolutionary in the detection of male fertility troubles?
Here, we’ll look at how the new test works and why it could change the male infertility sector forever.
What is the new male fertility test?
The new fertility health check, known as the Cap-Score, is designed to analyse the changes within a sperm cell which allow it to fertilise the egg. This provides much more advanced results compared to current tests and helps experts to more accurately diagnose male fertility issues.
Prolific doctor Alexander Travis, who was responsible for developing the test, was the first to recognise the ganglioside GM1 as a useful biomarker for the capacitation of sperm cells. Previous studies had already shown that the Cap-Score could differentiate between samples from men seeking help with fertility and fertile men. It also managed to detect between males who failed at intrauterine insemination and those who succeeded.
Cap-Score male fertility test study proves promising
The most recent Cap-Score study collected 208 semen samples from men who were undergoing medical evaluations regarding their fertility. As well as carrying out traditional semen analysis, the scientists tested the samples, arranging them into groups dependent upon their CAP-Score. Out of the 208 men, 91 reported clinical outcomes.
It was discovered through the study, that men who had a normal score, were 2.78 more likely to succeed at pregnancy than those with a low score. They also had a 4.23 increased chance of success for their first attempt using IUI. More interestingly, it discovered there was no relationship found between male fertility and factors such as sperm concentration and mobility which are typically assessed in traditional methods.
That wasn’t the end of the research either. The researchers then collected additional clinical outcomes and Cap-Scores from an additional five urology and fertility clinics. They used data from a further 124 men to develop a curve which translated a Cap-Score into the likelihood of achieving a pregnancy.
How does it compare to current testing?
The new Cap-Score testing is much more accurate at identifying the likelihood of achieving pregnancy than any current tests on the market. It is still designed to be used alongside traditional testing, but it offers a more definitive and clearer picture of a male’s fertility issues.
The researchers are hoping these results will enable specialists to introduce the new testing to personalise a patient’s journey into fatherhood. More targeted treatments will be able to be provided, saving couples time, money and emotional distress. Urologists are also going to be using the method to assess how different treatment plans, such as surgery and nutritional supplements, will affect male fertility.
The CAP-Score method has already started to be implanted into fertility clinics across America. However, it’s likely to take longer to reach across the pond. For the time being, traditional sperm analysis tests will continue to be used to identify male infertility.